14-Protein Blood Plasma Signature Predicts Lung Cancer Years Before Scans
A multinational team led by Charles Swanton (Francis Crick Institute, London) reported in Cell a 14-protein blood plasma signature (liquid biopsy) predicting lung cancer years before scans. Using AI/ML on 48,000 U.K. Biobank volunteers, it flags inflammatory changes, often triggered by smoking/air pollution that awaken dormant mutant cells. Retrospective CANTOS data showed canakinumab cut lung-cancer risk 50% in 2,300 signature-positive participants, but is toxic and costly.
The Hindu


